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Updates from the Children’s Hospital of Pittsburgh of UPMC Division of Pediatric Hematology/Oncology

PrintUpdates from the Children’s Hospital of Pittsburgh of UPMC Division of Pediatric Hematology/Oncology:

Jake Cooper, MD, Division of Pediatric Hematology/Oncology, published a paper on portomesenteric venous thrombosis in the journal Clinical Pediatrics.

Cheryl Hillery, MD, clinical director of Hematology in the Division of Pediatric Hematology/Oncology, was invited to be part of the NIH NHLBI Clinical Trials Review Committee.

Edward Prochownik, MD, PhD, Division of Pediatric Hematology/Oncology, published two manuscripts dealing witih drug development in the journal OncoTarget. OncoTarget’s mission is to make scientific results rapidly and widely available and to foster applications of basic and clinical science to fight disease. Dr. Prochownik published 12 manuscripts in 2014-15.

Mark Vander Lugt, MD, of the Division of Blood and Marrow Transplantation and Cellular Therapies, has developed a biorepository to collect and store samples from patients with primary immunodeficiencies and malignancies and who are undergoing hematopoietic stem cell transplant. The goal is to bank samples for future research in order to better understand the complex processes underlying these diseases.

Pediatric Pulmonology Division Chief Invited to Give Annual Lecture at University of Pennsylvania

Juan Celedón, MD, recently gave the Annual Nathan Francis Mossell Lecture at the University of Pennsylvania’s Perelman School of Medicine. The lecture is presented in recognition of the school’s first African American student, Nathan Mossell. Dr. Celedón’s presentation was titled “A Journey to Solve the Puzzle of Asthma Disparities.”

Adiposity, Fractional Exhaled Nitric Oxide, and Asthma in U.S. Children

A study led by Juan Celedon, MD; Yueh-Ying Han, PhD; and Erick Forno, MD, was recently published in the American Journal of Respiratory and Critical Care Medicine. This study aimed to examine adiposity, asthma, and fractional exhaled nitric oxide in children in the United States.

The full article is available here. 

UPMC Launches New Series: Video Rounds

UPMC has launched Video Rounds. Video Rounds is a series of informative and educational short videos, created for physicians and covering a variety of medical and surgical disciplines. New topics are always being added and include:

Endocrinology: Inpatient Diabetes Management
Gastroenterology: Developing a Center of Excellence for Pancreatic Disease Treatment
Geriatrics: Clinical Implications of Depression in the Geriatric Population
Gynecology: Advances in Prenatal Diagnosis of Genetic Conditions
Heart and Vascular: The Role of ECMO and VADs in Treating Acute Heart Failure
Neurosurgery: Microvascular Decompression in the Treatment of Cranial Nerve Disorders
Oncology: Using Big Data and Genomic Research to Develop Personalized Medicine
Ophthalmology: New Imaging Technology for Retinal Diseases
Orthopaedic Surgery: Diagnosis and Management of Diabetic Foot Infections
Pediatrics: Multidisciplinary Approach to Tongue-Based Airway Obstruction
Pulmonology: Endobronchial Coils to Treat Chronic Obstructive Pulmonary Disease
Rehabilitation: Early Mobility and Rehabilitation in the ICU: A Paradigm Shift
Rheumatology: A Primer of Myositis
Psychiatry: Considerations for Treating Women with Substance Use Disorder
Urology:Partial Nephrectomy: The Preferred Option for Treating Localized Kidney Cancer

The full video rounds library can be found here.

Analysis of Incidence and Survival After Liver Transplantation for Hepatoblastoma

In a recent study, researchers found that liver transplantations to treat hepatoblastoma are increasing, along with the overall incidence rate of the disease across the U.S. Favorable histology and early referral to surgery are increasingly linked to a greater chance of survival after resection, and could also determine improved post-transplantation outcomes.

Rakesh Sindhi, MD, director, Pediatric Transplant Research, Children’s Hospital of Pittsburgh of UPMC, talks about the results and implications of the study, which was published in the February 2013 issue of Surgery.


Novel vaccine strategies against tuberculosis

Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (Mtb), currently infects one third of the world’s population, resulting in 1.4 million deaths per annum.

Of the two billion latently infected individuals, 10% will progress to active TB during their lifetime. Unfortunately, the immune mechanisms that differ between individuals with latent and active TB remain undefined, a challenge that prevents the rational design of treatments or vaccines that may promote or improve the immune control of TB.

Using human and experimental models of Mtb infection,  recent studies delineate the distinct and diverse role of different T helper cells in conferring protection against Mtb infection. In addition, these studies delineate how cytokines such as Interleukin-17, can be targeted to improve vaccine strategies against TB. 

Learn more about TB research at Children’s Hospital of Pittsburgh of UPMC from assisant professor of pediatrics, Shabaana A Khader, PhD:

Clotting Time as a Monitoring Tool for Heparin Management in ECMO

Peter Wearden, MD, PhD, director, pediatric mechanical cardiopulmonary support, Children’s Hospital of Pittsburgh of UPMC, discusses recent findings on the use of activated clotting time as a monitoring tool for heparin management in ECMO.  These findings were recently published in Pediatric Critical Care Medicine.

Hear about the recently published paper from Dr. Wearden:

New Study May Help Duchenne Muscular Dystrophy

Hoda Abdel-Hamid, MD, a neuromuscular neurologist in the Brain Care Institute at Children’s Hospital of Pittsburgh of UPMC, discusses results to date of an exon-skipping clinical trial investigating Eteplirsen, a drug that may help boys diagnosed with Duchenne muscular dystrophy. 

Hear more about this study from Dr. Abdel-Hamid:

Can Amniotic Fluid Reduce the Risk of NEC?

A recent study by the National Institutes of Health, the Children’s Hospital of Pittsburgh Foundation, and the Hartwell Foundation determined that lack of exposure to amniotic fluid may be the reason preterm infants are more susceptible to the gastrointestinal inflammatory disease known as necrotizing enterocolitis (NEC).

Watch as senior study author, David Hackam, MD, PhD, co-director of the Fetal Diagnosis and Treatment Center at Children’s Hospital of Pittsburgh of UPMC, explains his team’s findings that feeding amniotic fluid to young mice, reduced the risk of NEC. This research suggests new therapeutic avenues for warding off this often deadly condition.

What role can amniotic fluid play in reducing the risk of NEC?

Determinants of Early Outcome in Pediatric Liver Transplantation

At the upcoming American Transplant Congress, George Mazariegos, MD, will present a session entitled, Pediatric Liver Transplantation, where he will discuss a recent study “Determinants of Early Outcome in Pediatric Liver Transplantation.”  

Although overall outcomes after pediatric transplantation (Tx) are very good, early death or graft loss contributes a significant proportion of overall mortality or retransplantation. The Studies in Pediatric Liver Transplantation (SPLIT) database was analyzed to determine factors predictive of 7 and 30 day mortality or graft loss. Multivariate models using factors available at the completion of Tx (baseline model) were compared to a model including 30 day chemistries and complication events (cumulative model).

Hear more about this presentation:

If you are attending the 2012 American Transplant Congress in Boston, consider attending the Pediatric Liver Transplantation session on June 5, at 2:39 p.m., in room 310.

Authors on the study include: G. V. Mazariegos, R. Anand, W. Yin, S. McDiarmid, J. M. Millis, J. Magee, B. Kelly, J. Bucuvalas, SPLIT Research Group. Children’s Hospital of Pittsburgh of UPMC; The EMMES Corporation; UCLA Children’s Health Center; Univ. of Chicago Medical Center; Univ. of Michigan Medical Center; Vanderbilt Univ. Medical Center; Cincinnati Children’s Hospital Medical Center

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