UPMC Physician Resources

Genetics of congenital corneal opacification affect diagnosis and treatment

In the May issue of Ocular Surgery News, Ken Nischal, MD, FRCOphth, provides an overview of a novel classification foe neonatal corneal opacification.

The full article is available here. 

What is the new classification for neonatal corneal opacification?


How does this classification allow for better phenotype and genotype correlation?


What evidence exists to support Peter’s anomaly 1 or 2 being a sign and not a diagnosis?


Why is it important to understand the child’s global development when making decisions regarding corneal transplant?

To ask questions of Dr. Nischal, please email EyeCenter@upmc.edu

 

UPMC Eye Center at ARVO 2015

The annual Association for Research in Vision and Ophthalmology (ARVO) conference begins next Sunday, May 3 in Denver.  ARVO is the leading conference for eye and vision research and this year the UPMC Eye Center, the Department of Ophthalmology at the University of Pittsburgh, has over 21 faculty members and 33 trainees taking part in the conference. There are more than 40 presentations as well from the Louis J. Fox Center for Vision Restoration of UPMC and the University of Pittsburgh.

Presentations from our researchers and faculty will highlight multiple areas of eye research including, regenerative ophthalmology (stem cell, small molecule, gene therapy, integrated bioengineered scaffolds and prostheses, etc.), optical imaging, immunology, microbiology, molecular biology and genetics and more.

A list of our faculty presentations is available here.  The full list of ARVO presentations can be found here. 

UPCI Researchers: Broccoli Sprout Extract Promising for Head and Neck Cancer Prevention

Physician-researchers at the University of Pittsburgh Cancer Institute recently found that broccoli sprout extract protects against oral cancer in mice and proved tolerable in a small group of healthy human volunteers. Because of these results, a human clinical trial will start to recruit patients who are at high risk for head and neck cancer recurrence. These findings were recently presented at the American Association for Cancer Research (AACR) Annual Meeting in Philadelphia.

Watch Julie Bauman, MD, MPH, co-director of the UPMC Head and Neck Cancer Center of Excellence, discuss this research.

Read the press release. 

International Society for Heart and Lung Transplantation (ISHLT) 35th Annual Meeting and Scientific Sessions

April 14-17, 2015

The UPMC Heart and Vascular Institute and UPMC Cardiothoracic Transplant Department are well-represented at the International Society for Heart and Lung Transplantation (ISHLT) 35th Annual Meeting and Scientific Sessions in Nice, France. Faculty research was featured in both oral and poster presentations throughout the conference, including:

Tuesday, April 14

MCS Master’s Academy
Chairs: Daniel Goldstein, Ulrich Jorde, Jim Kirklin, Robert Kormos, Stephan Schueler, Jeff Teuteberg

Section D – Decision making in the transition from acute temporary support to durable LVAD
Moderator: Robert Kormos

Section D – Conversion from Temporary to Durable MCS: The Challenges to Success
Presented by: Robert Kormos

Section E – RV failure, VT and AI
Moderator: Jeff Teuteberg

Section E – Case Presentation VT
Presented by: Jeff Teuteberg

Wednesday, April 15

Pre-meeting Symposium 01: Intermatics 0: Treatment of Shock
Are All INTERMACs Profile I Patients the Same? Definition, Categorization and Outcomes with Shock
Presented by: Jeff Teuteberg

Pre-meeting Symposium 11: Moving MCS Therapy Forward
Chair: Robert Kormos
Debate: All VAD recipients should be on heart failure medications
Con presented by: Jeff Teuteberg

Moderated Poster Session
Discussant: Robert Kormos
519 – Update on Post-Approval INTERMACs Registry of the HVAD System in Commercial Use
Presented by: S. Maltais, G. A. Ewald, M. E. Keebler, K. H. Schlendorf, S. W. Boyce, S. S. Najjar, F. D. Pagani, K. D. Aaronson, V. Jeevanandam, C. A. Milano, J. G. Rogers, R. B. Love, C. W. Mahr, D. T. Pham, M. S. Kiernan, R. L. Kormos, J. J. Teuteberg, S. C. Silvestry, E. C. McGee, R. A. Gordon, H. R. Mallidi, O. H. Frazier

Thursday, April 16

Concurrent Abstract Session 2: Anticoagulation for VADs
Chair: Jeff Teuteberg

Concurrent Abstract Session 9: Drivelines and Device Malfunction
49 – Device Malfunction in Contemporary Rotary Blood Pumps: The Relevant Burden of All Components
Presented by: R. L. Kormos, M. McCall, R. D. Schaub, K. L. Lockard, C. A. Bermudez, N. M. Kunz, E. M. Dunn, L. F. Lagazzi, J. J. Teuteberg

Concurrent Abstract Session 21: Kinetics, Coagulation, and Cardiology: Pharmacy of MCS and Transplant
Chair: Mike Shullo
121 – Assessing Anticoagulation Practice Patterns in Patients on Durable Mechanical Circulatory Support Devices: An International Survey
Presented by: D. L. Jennings, E. Horn, H. Lyster, A. Panos, J. Teuteberg, H. Lehmkuhl, W. Wolowich, M. Shullo

122 – Optimal Low Density Lipoprotein Levels Prevent Cardiac Allograft Vasculopathy
Presented by: J. Harris, J. Teuteberg, J. Coons, D. Winger, M. Shullo

Concurrent Abstract Session 16: Strokes, Arrhythmias and LVADs
95 – Temporal Differences in Adverse Event Rates in Patients Bridged with the HeartWare Left Ventricular Assist Device
Presented by: S. Maltais, K. D. Aaronson, J. J. Teuteberg, M. S. Slaughter, S. S. Najjar, V. Jeevanandam, D. T. Pham, E. C. McGee, K. Najarian, R. L. Kormos

Mini Oral Abstract Session 1: Fear and Loathing in MCS
127 – High Early Event Rates in Patients With Questionable Eligibility for Advanced Heart Failure Therapies
Presented by: A. V. Ambardekar, R. C. Forde-McLean, M. M. Kittleson, G. C. Stewart, M. Palardy, J. T. Thibodeau, A. D. DeVore, M. M. Mountis, L. Cadaret, J. J. Teuteberg, S. V. Pamboukian, R. S. Cantor, J. Lindenfeld

129 – Early Reassessment of Ambulatory Advanced Heart Failure Detects High-Risk Trajectories along a Dynamic Baseline
Presented by: G. C. Stewart, M. M. Mountis, M. M. Kittleson, A. V. Ambardekar, M. Palardy, R. C. Forde-McLean, J. T. Thibodeau, J. J. Teuteberg, S. V. Pamboukian, A. D. DeVore, L. Cadaret, R. S. Cantor, L. W. Stevenson

Friday, April 17
Plenary Session 2
Chair: Robert Kormos

Concurrent Abstract Session 23: Update on Short-Term Support
209 – A Prospective Multicenter Study to Evaluate Safety and Probable Benefit of a Novel Percutaneous Ventricular Assist Device for Right Ventricular Failure: The RECOVER RIGHT Study
Presented by: M. Anderson, J. Goldstein, L. Morris, C. Milano, R. Kormos, J. Bhama, N. Kapur, A. Bansal, J. Garcia, S. Silvestry, W. Holman, W. O’Neill

Concurrent Abstract Session 32: Mechanical Support and Children
258 – Adverse Events in Children Implanted With Ventricular Assist Devices in the U.S.: Data from the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS)
Presented by: D. N. Rosenthal, C. S. Almond, R. D. Jacquiss, C. E. Peyton, S. R. Auerbach, D. L. Morales, D. J. Epstein, R. S. Cantor, R. L. Kormos, D. C. Naftel, R. J. Butts, N. S. Ghanayem, J. K. Kirklin, E. D. Blume

Concurrent Abstract Session 37 – Fate of the RV after LVAD
Chair: Jeff Teuteberg
285 – Modeling the Spectrum of Right Ventricular Failure (RVF) after LVAD Therapy
Presented by: N. A. Loghmanpour, R. L. Kormos, M. K. Kanwar, J. J. Teuteberg, S. Murali, J. F. Antaki

286 – Update on Temporary Mechanical Circulatory Support for Right Ventricular Failure
Presented by: U. Bansal, K. Jackson, D. G. Winger, J. J. Teuteberg, C. Bermudez, R. L. Kormos, A. Bansal, J. K. Bhama

288 – An Analysis of Early Versus Late Right Heart Failure with an Intrapericardial Continuous Flow LVAD
Presented by: J. E. Rame, J. J. Teuteberg, E. J. Birks, J. G. Rogers, M. A. Acker, E. Y. Birati, M. S. Slaughter, K. D. Aaronson, K. Leadley, F. D. Pagani, R. L. Kormos

Concurrent Abstract Session 39: Advances in Prognostic Stratification in PH
299 – Hemodynamic Markers of Pulmonary Vascular Disease in Pulmonary Hypertension Due to Left Heart Disease
Presented by: R. R. Vanderpool, M. T. Gladwin, M. A. Simon

Mini Oral Abstract Session 11: What’s Up Doc? Bugs, Drugs, and PH.
370 – Characterization and Impact of Pulmonary Hypertension on Outcomes after Left Ventricular Assist Device Implantation
Presented by: V. N. Selby, J. J. Teuteberg, I. E. Allen, R. J. Tedford, R. L. Kormos, T. De Marco

For more information, visit the conference site.

News You Can Use: More studies comparing placement sites of tube shunts needed

In the April issue of Ocular Surgery News, Julia Polat, MD, discusses trabeculectomy and tube shunt implantation.

What has been the history of trabeculectomy versus tube shunt implantation?


What are the main issues with conventional tube shunt placement?


What are the main concerns with combined pars plana victrectomy and pars plana insertion?


Why has the ciliary sulcus placement of tube shunts gained attention recently?

The full article is available here. 

The Tumor Microenvironment Center: Enhancing and Accelerating Direct Patient-Oriented Interventions

The Tumor Microenvironment Center (TMC) is a collaboration between UPMC and the University of Pittsburgh Cancer Institute (UPCI). The TMC brings together preclinical and clinical scientists with the goal of translating basic knowledge of the mechanisms of interaction between cancer cells and their microenvironment, to enhance and accelerate direct patient-oriented interventions. Included in the microenvironment are the immune, inflammatory, and patient-specific factors that regulate cancer development, progression, and response to anti-cancer treatments.

Watch co-directors Robert Ferris, MD, PhD, FACS, and Dario Vignali, PhD, discuss the TMC.

Physicians and Researchers Present at the American College of Cardiology (ACC) 64th Annual Scientific Session

The UPMC Heart and Vascular Institute will be well-represented at the American College of Cardiology (ACC) 64th Annual Scientific Session in San Diego. Faculty research will be featured in both oral and poster presentations throughout the conference, including:

Friday, March 13, 2015

  • ASNC Fellows-in-Training Nuclear Cardiology Satellite Session
    LV function assessment, viability assessment
    Presented by: Prem Soman

Saturday, March 14, 2015

  • Epidemiology & Pathogenic Pathways in Pulmonary Arterial Hypertension
    Estimating the Prevalence of Pulmonary Hypertension Due to Left Heart Disease in Patients Undergoing a Right Heart Catheterization
    Presented by: Rebecca Vanderpool, Mark Gladwin, Marc Simon
  • Contemporary Challenges in Cardiac Implantable Device Management
    Extracting versus Abandoning Sterile Non-Functional or Recalled Leads
    Presented by: Shasank Rijal, Rashmee Shah, Samir Saba
  • Critical Care Cardiology Intensive
    Part Three – Management of Cardiac Arrest: It Takes a Village
    Presented by: Bojan Cercek, Dan J. Fintel, Kathleen Ryan Avery, Erin Ann Bohula May, Carmelo Graffagnino, James G. Jollis, Chere McCain, Robert Neumar, Sean Van Diepen, Mark Schmidhofer, Jeffrey B. Washam
  • Imaging the High-Risk Diabetic Patient: Joint Multimodality Imaging Symposium of the ASE/ASNC/SCCT/SCMR and the American College of Cardiology I
    Metabolism, Silent Ischemia, & Risk Detection with Nuclear Techniques
    Presented by: Prem Soman
  • Highlighted Original Research: Future of Cardiovascular Medicine, Science and Education
    CardioTalk: The Future of Communication Training in Cardiovascular Medicine
    Presented by: Katie Berlacher, Winnie Teuteberg, Eva Reitschuler-Cross, Robert Arnold

Sunday, March 15, 2015

  • What Constitutes Anti Arrhythmic Therapy for Atrial Fibrillation?
    Relaxin Suppresses Atrial Fibrillation in 24 Month Old Rats by Reversing Atrial Fibrosis and Upregulating Sodium Channels
    Presented by: Brian Henry, Ashish Parikh, Divyang Patel, Jamie Haney, Charles McTiernan, David Schwartzman, Sanjeev Shroff, Guy Salama
  • What Constitutes Anti Arrhythmic Therapy for Atrial Fibrillation?
    Adherence to Published Guidelines in Prescribing Anti-Arrhythmic Medications and its Impact on Clinical Outcomes of Atrial Fibrillation
    Presented by: Dingxin Quin, George Leef, Mian Bilal Alam, Rohit Rattan, Muhammad Bilal Munir, Divyang Patel, Furqan Habib Khattak, Nishit Vaghasia, Sandeep Jain, Samir Saba
  • What Constitutes Anti Arrhythmic Therapy for Atrial Fibrillation?
    Physician Adherence to Published Guidelines in Prescribing Anti-Arrhythmic Medications in the Management of Atrial Fibrillation
    Presented by: George Leef, Dingxin Quin, Mian Bilal Alam, Rohit Rattan, Muhammad Bilal Munir, Vivyang Patel, Furqan Habib Khattak, Nishit Vaghasia, Sandeep Jain, Samir Saba
  • Non-Invasive Imaging: Strain Imaging by Echocardiography
    Impairment in Left Ventricular Strain in Patients with Pulmonary Hypertension and Preserved Ejection Fraction Evaluated by Three Dimensional Speckle Tracking Echocardiography
    Presented by: Akiko Goda, Keiko Ryo, Antonia Delgado-Montero, Bhupendar Tayal, Marc Simon, Michael Mathier, John Gorcsan
  • Selected Applications for Echocardiography for Assessment of Left Ventricular & Right Ventricular Function
    Regional Contraction Heterogeneity Is Associated with Persistent Myocardial Dysfunction and Unfavorable Clinical Outcomes in Patients with Peripartum Cardiomyopathy
    Presented by: Bhupendar Tayal, Dennis McNamara, Joan Briller, Julie Damp, James Fett, Eileen Hsich, Kalgi Modi, Navin Rajagopalan, John Gorcsan
  • Novel Findings in the World of Electrophysiology
    Increased Non-Alternans Repolarization Variability of Intracardiac Electrogram Precedes Onset of Spontaneous Ventricular Arrhythmias in Patients with Implantable Defibrillator
    Presented by: Yuliya Krokhaleva, Divyang Patel, Hemal Shah, Vladimir Shusterman, Samir Saba, Jan Nemec
  • Imaging Biomarkers in Heart Failure
    Right Ventricular Size and Function at Presentation in Peripartum Cardiomyopathy Are Associated with Subsequent Left Ventricular Recovery
    Presented by: Lori Blauwet, Dennis McNamara, Antonia Delgado-Montero, Keiko Ryo, Josef J. Marek, Rami Alharethi, Paul J. Mather, Kalgi Modi, Richard Sheppard, Vinay Thohan, Jessica Pisarcik, John Gorcsan
  • Cardiac SPECT Imaging
    SPECT Imaging Provides Long-term Prognostic Value over Exercise Electrocardiography Alone in Patients with a Normal Baseline Electrocardiogram
    Presented by: Saurab Malhotra, Ravi K. Sharma, Deepak Kumar Pasupala, Mukul Khanna, Prem Soman
  • Cardiac SPECT Imaging
    Yield of SPECT Myocardial Perfusion Imaging in Chest Pain Patients with Negative ECG and Biomarkers
    Presented by: Gavin Hickey, Daniel Nguyen, Deepak Pasupula, Mukul  Khanna, Sanaz Abedzadeh Anaraki, Zachary Rhinehart, Omar Batal, Jeremy Markowitz, Omar Batal, Saurab Malhotra, Prem Soman
  • Cardiac SPECT ImagingConcordance Between Speckle Tracking Echocardiography and Phase Analysis of Myocardial Spect for LV Segment of Latest Mechanical ActivationPresented by: Hussein Abu Daya, Samir Saba, Serge Van Kriekinge, Didier Chalhoub,  Guido Germano, Daniel Berman, John Gorcsan, Prem Soman
  • Vascular Access: Approaches and Complications
    Radial Access: Tips, Tricks, Managing Complications
    Presented by: John Schindler
  • Training Directors Symposium II
    How to “Develop” Your Faculty
    Presented by: Julie Damp, Jeffrey T. Kuvin, Chittur A. Sivaram,   Katie Berlacher, Victor Soukoulis
  • Basic Practices, Applications and Novel Techniques in Nuclear Cardiology
    Getting up the Nerve to Image Cardiac Sympathetic Innervation with I-123 MIBG: Practical Considerations
    Presented by: Prem Soman

Monday, March 16, 2015

  • Future of Medical Education: Future of Cardiovascular Medicine IX
    Innovations in Medical Education: Simulation, Team-based Training (demonstration)
    Presented by: Katie Berlacher
  • Nuclear Cardiology: Applications in Clinical Practice
    Cardiomyopathies and Heart Failure
    Presented by: Prem Soman
  • Outcomes and Cardiac Device Therapy
    Impaired Baseline Global Circumferential Strain Is a Marker for Ventricular Arrhythmias After Resynchronization Therapy in Patients with Ischemic Cardiomyopathy
    Presented by: Antonia Delgado-Montero, Bhupendar Tayal, Akiko Goda, Stephanie Holt, David Schwartzman, Samir Saba, John Gorcsan
  • Outcomes and Cardiac Device Therapy
    Incidence of Ventricular Arrhythmias after Cardiac Resynchronization Defibrillator Therapy in Patients with Right Ventricular Pacing versus Intrinsic QRS Widening
    Presented by: Bhupendar Tayal, Antonia Delgado-Montero, Akiko Goda, Stephanie Holt, Samir Saba, David Schwartzman, Peter Søgaard, John Gorcsan
  • Outcomes and Cardiac Device Therapy
    Left Ventricular Regional Time Correlation by Echocardiographic Strain Analysis Is Predictive of Survival Free from Arrhythmias in Non-Left Bundle Branch Patients After Cardiac Resynchronization Therapy
    Presented by: Stephanie Holt, Bhupendar Tayal, Antonia Delgado-Montero, Sanjeev Shroff, David Schwartzman, Samir Saba, John Gorcsan
  • Long Term Care of LVAD Patients
    What to Do with the LVAD Patient Requiring Renal Replacement Therapy
    Presented by: Jeffrey Teuteberg
  • Non Invasive Imaging (Echocardiography, Nuclear, PET, MR and CT)
    Myocardial Tissue Characterization by CMR
    Presented by: Subha V. Raman, Erik B. Schelbert, Igor Klem, Matthias Friedrick, John Wood, Victor A. Ferrari 

For more information, visit the conference site.

Management of ROP continues to evolve

In the March edition of Ocular Surgery News, Christin Sylvester, DO,  discussed the use of bevacizumab in the treatment of retinopathy of prematurity . The full article is available here. 

1. What are the treatment modalities to decrease the progression of ROP?


2. Why is the BEAT-ROP study important and what were the results?


3. What other major research has contributed to the treatment of ROP? (Hu and Chen)


4. What questions should future research aim to answer?

To ask questions of Dr. Sylvester or for more information, email EyeCenter@upmc.edu

CyberKnife® Multileaf Collimator Now Available

A multileaf collimator for the CyberKnife ® M6 System is now available for clinical use, and we are pleased to announce that Mary Hillman Jennings Radiation Oncology Center at UPMC Shadyside has treated the first patient in the world using this new CyberKnife technology. The multileaf collimator allows for even more precise delivery of radiation by shaping radiation to the form of the tumor.

Watch Johnathan A. Engh, MD, and Steven Burton, MD, talk about the benefits of the multileaf collimator.

Pulmonary Grand Rounds: Chronic Obstructive Pulmonary Disease

Frank Sciurba, MD, FCCP, presented at a recent Pulmonary Grand Rounds on selected topics on chronic obstructive pulmonary disease (COPD).

In this presentation recap, Dr. Sciurba answers questions including:

  1. What is lung volume reduction and what is the current state of the surgical and bronchoscopic approaches?
  2. Why did endobronchial valves fail to gain approval after the VENT pivotal trial, and why is there promise that the new LIBERATE trial could demonstrate efficacy and safety?
  3. What is the evidence regarding endobronchial coil volume reduction, and what differences in patient selection are likely to be evident between endobronchial coil and valve volume reduction approaches?
  4. How are health care systems addressing the difficult problem of limiting COPD readmissions?

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