UPMC Physician Resources

Autophagy Inhibition as a Novel Treatment Strategy for Pancreatic Cancer

In preclinical studies, Herbert Zeh III, MD, Chief of the Division of GI Surgical Oncology, and colleagues have shown that pancreatic cancer is extremely dependent on autophagy for survival, and that drugs that block autophagy increase the sensitivity of pancreatic cancer cells to chemotherapy. Dr. Zeh’s research team is currently examining the promising clinical use of the autophagy inhibitor hydroxychloroquine, best known for its activity as an anti-malarial drug, in combination with chemotherapy for the treatment of pancreatic cancer.

Watch Dr. Zeh discuss recent advances in these clinical studies.

Pulmonary Grand Rounds: Non-Invasive Positive Pressure Ventilation

In a recent Pulmonary Grand Rounds presentation David Kristo, MD, discussed non-invasive positive pressure ventilation.

In this video recap Dr. Kristo answers the following questions:

  • What are the clinical indications for nocturnal ventilation support in patients with advanced lung disease?
  • How do we select patients for the various modes of NIV including BIPAP and AVAPS?
  • How do we measure a successful intervention for patients on NIV?
  • Can you describe the important features of a data download from a non-invasive ventilation device?

To review his full presentation, click here. 

Pulmonary Grand Rounds Summer 2015: Pulmonary Embolism

In a recent Pulmonary Grand Rounds, Belinda Rivera-Lebron, MD, MS, discussed acute and chronic pulmonary embolism.

In this recap, Dr. Rivera-Lebron answers the following questions:

  • What are the key clinical and biomarker parameters we can use to define mortality risk in the patient with pulmonary embolism?
  • Which patient with submassive pulmonary embolism should be selected for more advanced PE therapy than traditional anticoagulation?
  • When should local lytic/mechanical therapy for clot disruption be favored over systemic lysis?
  • How should patients with acute PE be monitored following hospitalization?

To review her full presentation, click here. 


Pulmonary Grand Rounds Summer 2015 – Making the Case for Early Palliative Care in IPF

Kathleen Lindell, PhD, RN, presented at a recent Pulmonary Grand Rounds on early palliative care in idiopathic pulmonary fibrosis (IPF).

In this video she recaps the following questions:

  • What do we know about the prognosis for patients with a confirmed diagnosis of IPF?
  • What are the common problems patients and their caregivers experience in the course of IPF?
  • How can we address dyspnea and anxiety (i.e. fear of dying) in the IPF patient population?
  • When in the IPF course should practitioners address end-of-life issues with the patient and their caregivers?

For the full slideshow, click here.


Temporal iridotomies may minimize visual side effects

In the June issue of Ocular Surgery News, Ian Conner, MD, PhD, discussed laser peripheral iridotomies. Dr. Conner discusses highlights of the article below. To read the full article, click here.

What do the research studies say about the position of laser peripheral iridotomies?

What position for the procedure does the UPMC Eye Center advocate?


What should ophthalmologists be mindful of while performing temporal iridotomy?

How can patency post-temporal iridotomy be confirmed?

To ask questions of Dr. Conner, email EyeCenter@upmc.edu


Genetics of congenital corneal opacification affect diagnosis and treatment

In the May issue of Ocular Surgery News, Ken Nischal, MD, FRCOphth, provides an overview of a novel classification foe neonatal corneal opacification.

The full article is available here. 

What is the new classification for neonatal corneal opacification?

How does this classification allow for better phenotype and genotype correlation?

What evidence exists to support Peter’s anomaly 1 or 2 being a sign and not a diagnosis?

Why is it important to understand the child’s global development when making decisions regarding corneal transplant?

To ask questions of Dr. Nischal, please email EyeCenter@upmc.edu


UPMC Eye Center at ARVO 2015

The annual Association for Research in Vision and Ophthalmology (ARVO) conference begins next Sunday, May 3 in Denver.  ARVO is the leading conference for eye and vision research and this year the UPMC Eye Center, the Department of Ophthalmology at the University of Pittsburgh, has over 21 faculty members and 33 trainees taking part in the conference. There are more than 40 presentations as well from the Louis J. Fox Center for Vision Restoration of UPMC and the University of Pittsburgh.

Presentations from our researchers and faculty will highlight multiple areas of eye research including, regenerative ophthalmology (stem cell, small molecule, gene therapy, integrated bioengineered scaffolds and prostheses, etc.), optical imaging, immunology, microbiology, molecular biology and genetics and more.

A list of our faculty presentations is available here.  The full list of ARVO presentations can be found here. 

UPCI Researchers: Broccoli Sprout Extract Promising for Head and Neck Cancer Prevention

Physician-researchers at the University of Pittsburgh Cancer Institute recently found that broccoli sprout extract protects against oral cancer in mice and proved tolerable in a small group of healthy human volunteers. Because of these results, a human clinical trial will start to recruit patients who are at high risk for head and neck cancer recurrence. These findings were recently presented at the American Association for Cancer Research (AACR) Annual Meeting in Philadelphia.

Watch Julie Bauman, MD, MPH, co-director of the UPMC Head and Neck Cancer Center of Excellence, discuss this research.

Read the press release. 

International Society for Heart and Lung Transplantation (ISHLT) 35th Annual Meeting and Scientific Sessions

April 14-17, 2015

The UPMC Heart and Vascular Institute and UPMC Cardiothoracic Transplant Department are well-represented at the International Society for Heart and Lung Transplantation (ISHLT) 35th Annual Meeting and Scientific Sessions in Nice, France. Faculty research was featured in both oral and poster presentations throughout the conference, including:

Tuesday, April 14

MCS Master’s Academy
Chairs: Daniel Goldstein, Ulrich Jorde, Jim Kirklin, Robert Kormos, Stephan Schueler, Jeff Teuteberg

Section D – Decision making in the transition from acute temporary support to durable LVAD
Moderator: Robert Kormos

Section D – Conversion from Temporary to Durable MCS: The Challenges to Success
Presented by: Robert Kormos

Section E – RV failure, VT and AI
Moderator: Jeff Teuteberg

Section E – Case Presentation VT
Presented by: Jeff Teuteberg

Wednesday, April 15

Pre-meeting Symposium 01: Intermatics 0: Treatment of Shock
Are All INTERMACs Profile I Patients the Same? Definition, Categorization and Outcomes with Shock
Presented by: Jeff Teuteberg

Pre-meeting Symposium 11: Moving MCS Therapy Forward
Chair: Robert Kormos
Debate: All VAD recipients should be on heart failure medications
Con presented by: Jeff Teuteberg

Moderated Poster Session
Discussant: Robert Kormos
519 – Update on Post-Approval INTERMACs Registry of the HVAD System in Commercial Use
Presented by: S. Maltais, G. A. Ewald, M. E. Keebler, K. H. Schlendorf, S. W. Boyce, S. S. Najjar, F. D. Pagani, K. D. Aaronson, V. Jeevanandam, C. A. Milano, J. G. Rogers, R. B. Love, C. W. Mahr, D. T. Pham, M. S. Kiernan, R. L. Kormos, J. J. Teuteberg, S. C. Silvestry, E. C. McGee, R. A. Gordon, H. R. Mallidi, O. H. Frazier

Thursday, April 16

Concurrent Abstract Session 2: Anticoagulation for VADs
Chair: Jeff Teuteberg

Concurrent Abstract Session 9: Drivelines and Device Malfunction
49 – Device Malfunction in Contemporary Rotary Blood Pumps: The Relevant Burden of All Components
Presented by: R. L. Kormos, M. McCall, R. D. Schaub, K. L. Lockard, C. A. Bermudez, N. M. Kunz, E. M. Dunn, L. F. Lagazzi, J. J. Teuteberg

Concurrent Abstract Session 21: Kinetics, Coagulation, and Cardiology: Pharmacy of MCS and Transplant
Chair: Mike Shullo
121 – Assessing Anticoagulation Practice Patterns in Patients on Durable Mechanical Circulatory Support Devices: An International Survey
Presented by: D. L. Jennings, E. Horn, H. Lyster, A. Panos, J. Teuteberg, H. Lehmkuhl, W. Wolowich, M. Shullo

122 – Optimal Low Density Lipoprotein Levels Prevent Cardiac Allograft Vasculopathy
Presented by: J. Harris, J. Teuteberg, J. Coons, D. Winger, M. Shullo

Concurrent Abstract Session 16: Strokes, Arrhythmias and LVADs
95 – Temporal Differences in Adverse Event Rates in Patients Bridged with the HeartWare Left Ventricular Assist Device
Presented by: S. Maltais, K. D. Aaronson, J. J. Teuteberg, M. S. Slaughter, S. S. Najjar, V. Jeevanandam, D. T. Pham, E. C. McGee, K. Najarian, R. L. Kormos

Mini Oral Abstract Session 1: Fear and Loathing in MCS
127 – High Early Event Rates in Patients With Questionable Eligibility for Advanced Heart Failure Therapies
Presented by: A. V. Ambardekar, R. C. Forde-McLean, M. M. Kittleson, G. C. Stewart, M. Palardy, J. T. Thibodeau, A. D. DeVore, M. M. Mountis, L. Cadaret, J. J. Teuteberg, S. V. Pamboukian, R. S. Cantor, J. Lindenfeld

129 – Early Reassessment of Ambulatory Advanced Heart Failure Detects High-Risk Trajectories along a Dynamic Baseline
Presented by: G. C. Stewart, M. M. Mountis, M. M. Kittleson, A. V. Ambardekar, M. Palardy, R. C. Forde-McLean, J. T. Thibodeau, J. J. Teuteberg, S. V. Pamboukian, A. D. DeVore, L. Cadaret, R. S. Cantor, L. W. Stevenson

Friday, April 17
Plenary Session 2
Chair: Robert Kormos

Concurrent Abstract Session 23: Update on Short-Term Support
209 – A Prospective Multicenter Study to Evaluate Safety and Probable Benefit of a Novel Percutaneous Ventricular Assist Device for Right Ventricular Failure: The RECOVER RIGHT Study
Presented by: M. Anderson, J. Goldstein, L. Morris, C. Milano, R. Kormos, J. Bhama, N. Kapur, A. Bansal, J. Garcia, S. Silvestry, W. Holman, W. O’Neill

Concurrent Abstract Session 32: Mechanical Support and Children
258 – Adverse Events in Children Implanted With Ventricular Assist Devices in the U.S.: Data from the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS)
Presented by: D. N. Rosenthal, C. S. Almond, R. D. Jacquiss, C. E. Peyton, S. R. Auerbach, D. L. Morales, D. J. Epstein, R. S. Cantor, R. L. Kormos, D. C. Naftel, R. J. Butts, N. S. Ghanayem, J. K. Kirklin, E. D. Blume

Concurrent Abstract Session 37 – Fate of the RV after LVAD
Chair: Jeff Teuteberg
285 – Modeling the Spectrum of Right Ventricular Failure (RVF) after LVAD Therapy
Presented by: N. A. Loghmanpour, R. L. Kormos, M. K. Kanwar, J. J. Teuteberg, S. Murali, J. F. Antaki

286 – Update on Temporary Mechanical Circulatory Support for Right Ventricular Failure
Presented by: U. Bansal, K. Jackson, D. G. Winger, J. J. Teuteberg, C. Bermudez, R. L. Kormos, A. Bansal, J. K. Bhama

288 – An Analysis of Early Versus Late Right Heart Failure with an Intrapericardial Continuous Flow LVAD
Presented by: J. E. Rame, J. J. Teuteberg, E. J. Birks, J. G. Rogers, M. A. Acker, E. Y. Birati, M. S. Slaughter, K. D. Aaronson, K. Leadley, F. D. Pagani, R. L. Kormos

Concurrent Abstract Session 39: Advances in Prognostic Stratification in PH
299 – Hemodynamic Markers of Pulmonary Vascular Disease in Pulmonary Hypertension Due to Left Heart Disease
Presented by: R. R. Vanderpool, M. T. Gladwin, M. A. Simon

Mini Oral Abstract Session 11: What’s Up Doc? Bugs, Drugs, and PH.
370 – Characterization and Impact of Pulmonary Hypertension on Outcomes after Left Ventricular Assist Device Implantation
Presented by: V. N. Selby, J. J. Teuteberg, I. E. Allen, R. J. Tedford, R. L. Kormos, T. De Marco

For more information, visit the conference site.

News You Can Use: More studies comparing placement sites of tube shunts needed

In the April issue of Ocular Surgery News, Julia Polat, MD, discusses trabeculectomy and tube shunt implantation.

What has been the history of trabeculectomy versus tube shunt implantation?

What are the main issues with conventional tube shunt placement?

What are the main concerns with combined pars plana victrectomy and pars plana insertion?

Why has the ciliary sulcus placement of tube shunts gained attention recently?

The full article is available here. 

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