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UPCI Researcher Awarded $6.3M for Studying How Food Can Lower Cancer Risks

Thomas Kensler, PhD, Professor of Pharmacology and Chemical Biology and Co-Leader of the UPCI Cancer Epidemiology and Prevention Program, was awarded a $6.3 million Outstanding Investigator Award from the National Cancer Institute (NCI). This new, 7-year award acknowledges experienced researchers and provides them with long-term support for their exceptional work. Dr. Kensler’s research focuses on chemoprevention, […]

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Autophagy Inhibition as a Novel Treatment Strategy for Pancreatic Cancer

In preclinical studies, Herbert Zeh III, MD, Chief of the Division of GI Surgical Oncology, and colleagues have shown that pancreatic cancer is extremely dependent on autophagy for survival, and that drugs that block autophagy increase the sensitivity of pancreatic cancer cells to chemotherapy. Dr. Zeh’s research team is currently examining the promising clinical use of […]

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UPCI Researchers: Broccoli Sprout Extract Promising for Head and Neck Cancer Prevention

Physician-researchers at the University of Pittsburgh Cancer Institute recently found that broccoli sprout extract protects against oral cancer in mice and proved tolerable in a small group of healthy human volunteers. Because of these results, a human clinical trial will start to recruit patients who are at high risk for head and neck cancer recurrence. These […]

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The Tumor Microenvironment Center: Enhancing and Accelerating Direct Patient-Oriented Interventions

The Tumor Microenvironment Center (TMC) is a collaboration between UPMC and the University of Pittsburgh Cancer Institute (UPCI). The TMC brings together preclinical and clinical scientists with the goal of translating basic knowledge of the mechanisms of interaction between cancer cells and their microenvironment, to enhance and accelerate direct patient-oriented interventions. Included in the microenvironment are […]

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CyberKnife® Multileaf Collimator Now Available

A multileaf collimator for the CyberKnife ® M6 System is now available for clinical use, and we are pleased to announce that Mary Hillman Jennings Radiation Oncology Center at UPMC Shadyside has treated the first patient in the world using this new CyberKnife technology. The multileaf collimator allows for even more precise delivery of radiation […]

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Chemotherapy and SABR May Be Promising Treatment for Advanced Pancreatic Cancer

Pancreatic cancer is often diagnosed at a late stage with locally advanced disease making surgery to remove the tumor difficult. A recent study at UPMC CancerCenter, partner with University of Pittsburgh Cancer Institute, evaluated patients treated with a combination of chemotherapy and stereotactic ablative radiation (SABR). With a total of 34 patients in the trial, […]

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UPCI Physician-Researchers Find Targeted Radiation, Drug Therapy Combo Less Toxic for Treatment of Recurrent Head, Neck Cancers

Physician-researchers at the University of Pittsburgh Cancer Institute (UPCI)/ UPMC CancerCenter  report that patients with a recurrence of head and neck cancer who have previously been given radiation can be treated more quickly, safely, and with less side effects with high doses of Stereotactic Body Radiation Therapy (SBRT) in combination with the drug cetuximab. Between […]

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UPCI Scientists Find Patients With Invasive Lobular Carcinoma May Benefit From Personalized Drug Therapies

According to a multidisciplinary team led by scientists at the University of Pittsburgh Cancer Institute (UPCI), invasive lobular carcinoma (ILC), the second-most common type of breast cancer, appears to be a good candidate for a personalized approach to treatment. Patients with ILC are typically treated with surgery and chemotherapy or hormone therapy, or both. According […]

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Study Finds Some Metastatic Breast Cancer Patients May Benefit From Surgery Before Other Treatment

According to early results from a first-of-its kind clinical trial, newly diagnosed patients with advanced breast cancer and a solitary bone metastasis may benefit from surgery prior to other treatment. The study comprised of 278 patients with advanced breast cancer, 140 of whom underwent breast cancer surgery. The goal of the study was to assess […]

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Study: Accurately Identifying Neck Tumors Using Robotics Improves Treatment, Survival

Researchers at the University of Pittsburgh Cancer Institute (UPCI) recently found that by using robotic surgery done through the mouth to identify the cause of lumps in the neck, physicians can better target more personalized therapies for patients and dramatically improve survival. In the study, researchers examined 206 head and neck robotic cases performed at […]

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