The UPMC Heart and Vascular Institute and UPMC Cardiothoracic Transplant Department will be well-represented at the International Society for Heart and Lung Transplantation (ISHLT) 36th Annual Meeting and Scientific Sessions in Washington, DC. Faculty research will be featured in both oral and poster presentations throughout the conference, including:

Wednesday, April 27

Pre-Meeting Symposium 01: Anticoagulation and MCS: Can We Do Better?

Co-Chair: Michael A. Shullo

Pre-Meeting Symposium 06: Back to the Future: Cell Therapy for Thoracic Organ Failure and Transplant?

Myeloid Cells to Induce Transplant Tolerance

Presented by: Angus Thomson

Pre-Meeting Symposium 07: The Future is Here: Emerging Issues in Infectious Disease

Mycobacterium Abscessus and Friends

Presented by: Fernanda Silveira

Pre-Meeting Symposium 13: Child’s Play: Infectious Risk After Transplant During Everyday Life

Outbreak – Measles, Varicella and Mumps

Presented by: Marian G. Michaels

Pre-Meeting Symposium 16: When Right is Wrong! Management of the Dying Right Ventricle

Peering Through the Looking Glass: Imaging the Right Ventricle

Presented by: Marc A. Simon

Pre-Meeting Symposium 19: Between a Rock and a Hard Place: Debating Treatment Decisions for Marginal Psychosocial Candidates

DEBATE 3: Substance Use: It’s OK To Dabble (PRO)

Presented by: Mary Amanda Dew

Pre-Meeting Symposium 22: Great Debates in MCS

DEBATE 2: INTERMACS 4-7: The Time is Now (PRO)

Presented by: Jeffrey J. Teuteberg

Pre-Meeting Symposium 28: Lifecycle Journey of Hepatitis C Heart Failure Patient in 2016

Immunosuppression— A Tricky Balance?

Presented by: Michael Shullo

Poster Session 1: Basic Science

0474 – Refinement of Ex Vivo Lung Perfusion Techniques for Better Microvasculature Maintenance in Lung Grafts

Presented by: K. Noda, S. Haam, Y. Wu, J. D’Cunha, J. D. Luketich, N. Shigemura

0490 – Identification of Hypoxic Cells in Lung Grafts for Future Cell Targeted Therapy for Obliterans Bronchiolitis

Presented by: K. Noda, H. Hara, S. Haam, J. D’Cunha, J. D. Luketich, N. Shigemura

0500 – CD8+ IL-17 Responses and Obliterative Airway Disease Persist in T-bet-/- Mouse Recipients of Lung Transplant Treated with Low Dose Azithromycin Therapy

E. A. Lendermon, J. M. Dodd-o, L. Guo, T. A. Coon, C. R. Ensor, C. P. O’Donnell, J. F. McDyer

 0505 – Relationship between Grafts’ Quality, Glucose Consumption and IL-6 Production during Ex Vivo Lung Perfusion

Presented by: K. Noda, S. Haam, J. D’Cunha, J. D. Luketich, N. Shigemura

0551 – Poor Blood Pressure Control Is Independently Associated with Renal Dysfunction After Heart Transplant

Presented by: M. Osnard, A. D. Althouse, L. Krall, C. Newman, C. Grabowski, F. Speicher, R. Zomak, L. Lagazzi, R. L. Kormos, M. Shullo, J. J. Teuteberg

Poster Session 1: Lung Transplantation

0646 – Pre-Treatment High Titer DSA Is Associated with Non-Responsiveness to Carfilzomib-Based AMR Therapy in Lung Transplant Recipients

Presented by: A. Zeevi, M. Marrari, M. R. Morrell, S. A. Yousem, J. M. Pilewski, J. D’Cunha, J. F. McDyer, C. R. Ensor.

Poster Session 1: Mechanical Circulatory Support

0706 – Right Ventricular Failure in Patients with Left Ventricular Assist Devices Is Associated with Downregulated Chemokine Receptors and Altered Right Ventricular Pressure Waveforms

Presented by: T. N. Bachman, R. Vanderpool, M. Jacus, A. Nayak, O. Hunter, A. Inashvili, L. Lagazzi, J. J. Teuteberg, C. McTiernan, K. Hanley-Yanez, D. McNamara, R. L. Kormos, M. Simon

0717 – Worsening Renal Function after Ventricular Assist Device Placement Is Associated with Twice the Risk of Death over 3 Years

Presented by: J. E. Holtz, A. N. Potter, N. C. Macpherson, D. Nguyen, R. L. Kormos, J. J. Teuteberg, J. A. Kellum

Thursday, April 28

Concurrent Session 07: It’s Tough to Make Predictions, Especially about the Future: Outcomes in MCS

Abstract Session Chair: Jeffrey J. Teuteberg

0039 – Insights from INTERMACS into Patient Characteristics Leading to Futility in LVAD Therapy

Presented by: R. L. Kormos, F. D. Pagani, A. D. Althouse, L. Warner Stevenson, J. J. Teuteberg, J. B. Young, J. K. Kirklin

Concurrent Session 08: Quality Over Quantity? Quality of Life in MCS

Abstract Session Chair: Mary Amanda Dew

 Concurrent Session 11: The Heartbreak of Rejection: All Against the Graft

0066 – Initial Analysis of the Donor-Derived Cell-Free DNA – Outcomes AlloMap Registry (D-OAR) Study in Heart Transplant Recipients Undergoing Surveillance for Rejection

Presented by: J. A. Kobashigawa, K. Khush, J. J. Teuteberg, M. Song, M. Grskovic, D. Hiller, R. Woodward, E. Deljkich, J. Yee, F. Latif, N. Sulemanjee, S. Murali

Concurrent Session 15: Let’s Be Specific: Donor Specific Antibodies – Challenges Ahead

The Timeline of DSA after Cardiac Transplantation

Presented by: A Vu, J. J. Teuteberg, A. Zeevi, M. A. Shullo

Mini Oral 04: Donor and Recipient Management in Lung Transplantation

0165 – On-Demand Immunoglobulin-G Replacement Is Not Associated with Benefits in Lung Transplant Recipients with Hypogammaglobulinemia

Presented by: A. B. Lichvar, C. R. Ensor, M. R. Morrell, J. M. Pilewski, J. Hayanga, J. D’Cunha, A. Zeevi, J. F. McDyer, A. A. Petrov

 0166 – Carfilzomib-Based Therapy Produces Favorable Outcomes for Antibody Mediated Rejection of the Lung Allograft

Presented by: C. R. Ensor, A. Zeevi, M. Marrari, M. R. Morrell, S. A. Yousem, J. M. Pilewski, J. D’Cunha, J. F. McDyer

0168 – Extracorporeal Membrane Oxygenation (ECMO) as a Bridge to Lung Transplantation: Identifying Predictors of Mortality

Presented by: J. A. Hayanga, N. Shigemura, E. Chan, T. Richards, M. Morrell, J. D. Luketich, J. D’Cunha

Mini Oral 06: Pharmacy & Pharmacology and Mechanical Circulatory Support

0184 – CYP3A5 Pharmacogenetic Testing Predicts High Tacrolimus Dose Requirements Early after Cardiac Transplantation

Presented by: K. M. Deininger, A. Vu, R. L. Page II, A. V. Ambardekar, J. Lindenfeld, C. L. Aquilante

Poster Session 2: Heart Transplantation

0783 – Simple Technique for Open Sternal Wound Closure after Cardiac Transplant or LVAD

Presented by: U. Bansal, A. Bansal, J. K. Bhama

Poster Session 2: Lung Transplantation

0846 – Donor Derived Disease Transmission Events in Thoracic Organ Transplantation: Data Reviewed by the OPTN Ad Hoc Disease Transmission Advisory Committee

Presented by: J. M. Schaenman, A. Wilk, S. Tlusty, M. A. Nalesnik, M. G. Michaels, C. Wolfe, D. Kaul

0866 – Soluble CD14 and LBP as Markers for Primary Graft Dysfunction

Presented by: K. Ramphal, E. Cantu, M. Porteous, M. Oyster, S. Kawut, D. J. Lederer, R. Shah, S. Arcasoy, L. Snyder, M. Hartwig, S. Palmer, K. M. Wille, L. Ware, P. Shah, M. Crespo, C. Hage, A. Weinacker, V. Lama, Y. Suzuki, J. Orens, J. D. Christie, J. Diamond

Poster Session 2: Nursing, Health Sciences, Allied Health

0960 – Tales of Roller Coaster Rides and Resilience: Lung Transplant Caregivers in Their Own Words

Presented by: A.J. Haines

Poster Session 2: Pediatrics

0982 – Cost Effectiveness of Ventricular Assist Device Destination Therapy for Advanced Heart Failure in Duchenne Muscular Dystrophy

Presented by: D. A. Magnetta, J. Kang, P. D. Wearden, K. J. Smith, B. Feingold

Poster Session 2: Pulmonary Hypertension

1004 – PVR Predicts Cardiac Hospitalizations in Pulmonary Hypertension Associated with HFpEF and HFrEF

Presented by: R. R. Vanderpool, M. Saul, S. Nouraie, M. T. Gladwin, M. A. Simon

Friday, April 29

Sunrise Symposium 03: Thoracic Organ Transplantation and Malignancy

Lung Transplantation for Patients with Chronic GVHD Following Allogeneic Stem Cell Transplant

Presented by: Samuel Goldfarb

 Concurrent Session 24: What’s New in Primary Graft Dysfunction Post Lung Transplantation

0214 – Plasma RIP3 Is Decreased in PGD after Lung Transplantation

Presented by: A. D’Errico, M. Hotz, E. Cantu, M. Porteous, M. Oyster, R. Shah, S. Arcasoy, L. Snyder, K. M. Wille, M. Hartwig, L. B. Ware, P. Shah, M. Crespo, C. Hage, A. Weinacker, V. Lama, Y. Suzuki, J. Orens, S. Kawut, S. Palmer, D. J. Lederer, J. D. Christie, N. Mangalmurti, J. M. Diamond

Concurrent Session 25: Beyond Adherence: What’s New Out There?

0221 – Medical Adherence in the Late-Term after Lung Transplant

Presented by: K. R. Fox, A. J. DeVito Dabbs, A. F. DiMartini, D. M. Posluszny, E. M. Rosenberger, J. M. Pilewski, M. A. Dew

Concurrent Session 27: Are Two Pumps Better Than One? RV Failure and MCS

0232 – Risk Factors Associated with Right Ventricular Assist Device Implantation: Insights from INTERMACS

Presented by: M. S. Kiernan, D. DeNofrio, D. T. Pham, N. K. Kapur, R. Ruthazer, E. W, J. E. Rame, P. Alturi, E. Y. Birati, S. L. Myers, G. H. Oliveira, J. K. Kirklin, R. L. Kormos, F. D. Pagani, J. J. Teuteberg

0234 – Chemokine Receptor Down Regulation in Mechanical Circulatory Support Patients with Right Ventricular Failure

Presented by: A. Nayak, T. N. Bachman, K. Hanley-Yanez, C. McTiernan, D. McNamara, R. L. Kormos, O. Hunter, A. Inashvili, L. Lagazzi, J. J. Teuteberg, M. A. Simon

Concurrent Session 34: How Much is Too Much? Assessing Risk Prior to MCS

0275 – Physician Prediction of Outcomes in Ambulatory Patients with Advanced Heart Failure

Presented by: M. M. Kittleson, C. B. Patel, R. S. Cantor, A. D. DeVore, A. V. Ambardekar, J. T. Thibodeau, L. M. Cadaret, S. V. Pamboukian, J. J. Teuteberg, R. C. Forde-McLean, M. M. Mountis, M. Palardy, G. C. Stewart, M. A. Hamilton

Concurrent Session 40: Too Much of a Good Thing: Balancing Benefit and Medication Complexity

0315 – Effect of Aerosolized Antipseudomonals on Pseudomonas Recurrence and Bronchiolitis Obliterans Syndrome after Lung Transplantation

Presented by: C. A. Moore, J. M. Pilewski, K. M. Robinson, M. R. Morrell, C. J. Gries, A. Zeevi, J. F. McDyer, C. R. Ensor

Mini Oral 07: Patient Management and Outcomes in MCS

0693 – When Antibiotics Are Not Enough: Frequency, Etiology and Durability of the Surgical Management of Driveline Infections

Presented by: M. Lander, L. Lagazzi, R. L. Kormos, G. O’Shea, S. Weaver T. Schweke, M. Shullo, J. J. Teuteberg

0326 – Log Files from the HVAD: What Can Daily and Long-Term Changes in Flow Tell Us about Patients?

Presented by: A. Potter, S. Anderson, J. J. Teuteberg, R. L. Kormos, J. Holtz

Mini Oral 09: Risk Factors and Lung Transplant Outcomes

0343 – Outcomes in Lung Transplant Recipients with Mycobacterium Abscessus Infection

Presented by: Y. Hamad, J. M. Pilewski, J. D’Cunha, E. J. Kwak

0351 – Interleukin 12-Dependent CMV-Specific CD4+ T Cell Proliferation, T-bet Induction and Effector Function During Primary Infection Are Key Determinants for Early Immune Control in Lung Transplant Recipients

Presented by: I. Popescu, M. R. Pipeling, H. Mannem, P. D. Shah, J. B. Orens, J. F. McDyer

Mini Oral 11: Models in Transplantation: From Mouse to Rat to Pig to Human

0369 – Cyclosporine A Can Mitigate Mitochondrial Dysfunction in Lung Grafts during Ex Vivo Lung Perfusion: A Potent Contributor for Better Preconditioning

Presented by: S. Haam, K. Noda, J. D’Cunha, J. D. Luketich, N. Shigemura

0477 – Circulating Cytokines vs. Leukocytes: A Therapeutic Target during Ex Vivo Lung Perfusion

Presented by: K. Noda, S. Haam, D. Zaldonis, J. D’Cunha, J. D. Luketich, N. Shigemura

Poster Session 3: Junior Faculty Case Reports

1237 – Pulmonary Kaposi’s Sarcoma after Lung Transplantation, with 2-Year Follow-Up

Presented by: J. Yoon, N. Shigemura, J. D’Cunha, M. Mehrad, M. Pipeling

Poster Session 3: Lung Transplantation

1026 – The Paradoxical Impact of Warm Ischemia on Lung Allograft Survival

Presented by: C. D. Odell, E. Chan, N. Shigemura, M. R. Morrell, M. M. Crespo, J. M. Pilewski, J. D. Luketich, J. D’Cunha

Poster Session 3: Mechanical Circulatory Support

1042 – A Novel Combined Endpoint Integrating Quality of Life Can Inform Decisions about VAD in Ambulatory Advanced Heart Failure

Presented by: G. C. Stewart, A. V. Ambardekar, M. M. Kittleson, M. Palardy, A. DeVore, J. T. Thibodeau, J. J. Teuteberg, L. M. Cadaret, R. C. Forde-McLean, M. M. Mountis, S. V. Pamboukian, R. Cantor, R. Xie, L. W. Stevenson

1056 – Characteristics of Non-Compliant (NC) LVAD Patients

Presented by: J. Larsen, E. M. Dunn, N. M. Kunz, K. L. Lockard, J. J. Teuteberg, L. Lagazzi, A. D. Althouse, R. L. Kormos

1083 – No Pulse, No Problem! Measuring Blood Pressure and Estimating Pulse Pressure in Centrifugal Flow Left Ventricular Assist Devices

Presented by: J. E. Holtz, A. N. Potter, B. C. Lampert, L. Lagazzi, R. L. Kormos, J. J. Teuteberg

Poster Session 3: Pediatrics

1126 – The Impact of Age on the Incidence and Prevalence of Moderate to Severe Cellular Rejection Detected by Routine Surveillance Biopsy in Pediatric Heart Transplantation

Presented by: M. D. Zinn, K. E. Simpson, M. J. Wallendorf, A. D. Osborne, J. K. Kirklin, C. E. Canter

1139 – Impact of Routine Surveillance Biopsy Intensity on the Diagnosis of Moderate to Severe Cellular Rejection and Survival After Pediatric Heart Transplantation

Presented by: M. D. Zinn, K. E. Simpson, M. J. Wallendorf, A. D. Osborne, J. K. Kirklin, C. E. Canter.

1152 – Pediatric Myocarditis in a Contemporary Multi-Center Cohort

Presented by: R. J. Butts, G. J. Boyle, S. Deshpande, K. Gambetta, K. Knecht, C. Prada Ruiz, M. Richmond, S. West, A. Lal

1155 – Pediatric Myocarditis: Variations in Immunotherapy and Impact on Outcomes

Presented by: K. Gambetta, G. J. Boyle, R. J. Butts, K. R. Knecht, A. K. Lal, Y. Law, A. Prada-Ruiz, M. E. Richmond, S. C. West, S. R. Deshpande

Poster Session 3: Pharmacy & Pharmacology

1175 – Tacrolimus Immunosuppressive Regimens Are Associated with a Mortality Benefit in Lung Transplantation Recipients at a High-Volume Single Center

Presented by: A. B. Lichvar, M. R. Morrell, J. Hayanga, J. M. Pilewski, M. M. Crespo, J. D’Cunha, A. Zeevi, J. F. McDyer, C. R. Ensor

1181 – Mycophenolate-Based Immunosuppressive Regimens Are Associated with a Mortality Benefit in Lung Transplantation Recipients at a Single High-Volume Center

Presented by: A. B. Lichvar, M. R. Morrell, J. Hayanga, J. M. Pilewski, M. M. Crespo, J. D’Cunha, A. Zeevi, J. F. McDyer, C. R. Ensor

Saturday, April 30

Concurrent Session 45: Pediatric Heart Failure

0412 – Risk Factors at Presentation Predict Outcomes of Pediatric Myocarditis: A Contemporary Multi-Center Cohort

Presented by: S. C. West, G. J. Boyle, R. J. Butts, S. R. Deshpande, K. Gambetta, K. R. Knecht, A. K. Lal, Y. Law, A. C. Prada-Ruiz, M. Richmond

Plenary Session – Pushing New Scientific Frontiers: It’s In Our Heritage

April 30, 2016, 9:45 AM – 11:45 AM

Co-Chair: Jeffrey J. Teuteberg

Lifetime Achievement Award to Adrian and Jean Kantrowitz

Presented by: Robert L. Kormos

Concurrent Session 48: Not Just to Survive, But to Thrive: Comprehensive Care of the MCS Patient

0435 – Substantial Reduction in Driveline Infection Rates with the Modification of Driveline Dressing Protocols

Presented by: M. Lander, N. Kunz, E. Dunn, K. Lockard, G. O’Shea, S. Weaver, T. Schweke, M. A. Shullo, L. Lagazzi, R. L. Kormos, J. J. Teuteberg

ISHLT Academy: Master Class in Mechanical Circulatory Support

SECTION B: Case Scenario: Chronic infection management on durable support and thromboembolic complication

Presented by: Robert L. Kormos

 For more information, visit the event website.